In a large mixing bowl, combine the ground beef with garlic powder, onion powder, smoked paprika, salt, and pepper. Mix with your hands or a spoon until just integrated; be careful not to overmix, which can make the burgers tough.
Divide the seasoned beef mixture into four evenly sized portions. Shape each portion into a patty, pressing a slight indentation in the center to help them cook evenly.
Heat a large skillet or an outdoor grill over medium-high heat, then add the olive oil. Once the oil is hot, carefully add the patties to the skillet or grill and cook for approximately 4-5 minutes on each side, flipping them only once, until they reach your preferred level of doneness.
In the last minute of cooking, place a slice of cheddar cheese atop each patty, allowing it to melt perfectly as the burgers finish cooking.
While the burgers are cooking, prepare your lettuce wraps by gently separating the romaine leaves, rinsing them under cool water, and patting them dry with a towel. Select the largest and most intact leaves; these will serve as your burger wraps.
To assemble your burger wraps, take one lettuce leaf and place a cheese-topped patty in the center. Add a few slices of fresh tomato, a couple of rings of red onion, and a few pickles for crunch and flavor.
Drizzle ketchup and mustard over the fillings for that classic burger taste. Carefully wrap the sides of the lettuce around the fillings to create a handheld burger experience.
Enjoy your delicious burger wraps immediately while the patties are warm and juicy!